Age dependence of myocardial Na+-K+-ATPase activity and digitalis intoxication in the dog and guinea pig.

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Population

Adult, 1-week-old, and 6-week-old dogs and guinea pigs

Comparison

In vitro myocardial uptake of rubidium and… vs Comparison across age groups

Design

Preclinical

Authors

Discussion

Greater digoxin tolerance in young animals may reflect higher Na-K-ATPase activity; leaves open translation to human pediatric dosing.

Population

Adult, 1-week-old, and 6-week-old dogs and guinea pigs

Intervention

In vitro myocardial uptake of rubidium (86Rb) and binding of ouabain; in vivo digoxin 0.3 mg/kg iv in dogs

Comparator

Comparison across age groups (1-week-old vs 6-week-old vs adult)

Outcome

Myocardial Na+-K+-ATPase activity (measured by rubidium uptake and ouabain binding) and time to cardiotoxicity after digoxin administrationsurrogate

Increased myocardial Na+-K+-ATPase activity in young animals may partly explain their greater tolerance to digitalis glycosides compared to adults.

Marsh et al. (1981) studied this question.

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