Population
Dog hearts rendered ischemic for 15, 30, and 60 min via left anterior descending artery occlusion
Comparison
Digitalis receptor characterization via… vs Normal dog hearts
Design
Preclinical
Follow-up
up to 60 minutes of ischemia
Authors
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May support caution with digitalis in ischemia; leaves open clinical translation of receptor changes.
Ischemia causes a loss of high-affinity inotropic digitalis receptors while preserving low-affinity toxic receptors, explaining the increased toxicity and reduced efficacy of digitalis in ischemic hearts.
Maixent et al. (1987) studied this question.
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