Key result
Long-term digoxin treatment did not upregulate digitalis glycoside receptor concentration in human left ventricle samples compared to unexposed controls (14% lower, P>0.10).
Why the study?
Does long-term digoxin treatment upregulate digitalis glycoside receptor (Na,K-ATPase) concentration in human myocardial tissue?
Observational (n=19)
Does long-term digoxin treatment upregulate digitalis glycoside receptor (Na,K-ATPase) concentration in human myocardial tissue?
Long-term digoxin treatment does not upregulate digitalis glycoside receptors in the human heart, suggesting that tolerance to digoxin therapy does not develop at the receptor level.
Answers are grounded in this paper and cite their sources.
No Na,K-ATPase upregulation with digitalis in autopsy samples; leaves open mechanisms of benefit in heart failure.
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Schmidt et al. (1991) conducted an observational in Heart failure (n=19). Long term digoxin treatment vs. No previous digoxin treatment was evaluated on Digitalis glycoside receptor (Na,K-ATPase) concentration after washing (14% lower, p=>0.10). Long-term digoxin treatment did not upregulate digitalis glycoside receptor concentration in human left ventricle samples compared to unexposed controls (14% lower, P>0.10).
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