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February 29, 1956American Journal of Physiology-Legacy Content

Effects of Digitalis and Hypoxia on Potassium Transfer and Distribution in the Dog Heart

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Why the study?

Do digitalis and hypoxia alter potassium transfer and distribution in the normal intact dog heart?

Population

Normal intact dogs

Design

Preclinical

Authors

HCHadley L. ConnBrunswick (United States)

Discussion

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Implication

May warrant caution with digitalis in hypoxia; leaves open translation from canine models to human therapeutics.

Structured PICO

Do digitalis and hypoxia alter potassium transfer and distribution in the normal intact dog heart?

P
Population
Normal intact dogs
I
Intervention
Moderately severe hypoxia and moderately large doses of digitalis
O
Outcome
Potassium kinetics and distribution in the left ventriclesurrogate

Digitalis partially inhibits potassium transfer into the myocardial cell, and aerobic metabolism is necessary for potassium transfer in the heart.

Cite This Study

Hadley L. Conn (1956) studied this question.

synapsesocial.com/papers/6a912a95ca59a4cbdea1525fhttps://doi.org/10.1152/ajplegacy.1956.184.3.548
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Differential inactivation of inotropic and toxic digitalis receptors in ischemic dog heart. Molecular basis of the deleterious effects of digitalis.1987 · 31 citations
  2. 2Effect of Potassium and "Toxic" Doses of Digitalis on the Myocardium1959 · 34 citations
  3. 3Correlation of the Electrophysiological and Mechanical Changes in the Dog Heart during Digitalis Administration, and the Effect of Potassium on It1975
  4. 4Interrelation between Potassium Metabolism and Digitalis Toxicity in Heart Failure.1951 · 81 citations
  5. 5Effects of Digitalis Upon Body Electrolytes1961 · 12 citations