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November 1, 1972British Journal of PharmacologyOpen Access

Species and ionic influences on the accumulation of digitalis glycosides by isolated perfused hearts

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Why the study?

How do species differences and ionic composition affect the accumulation of polar and non-polar digitalis glycosides in isolated perfused hearts?

Population

Isolated perfused guinea-pig (digitalis-sensitive species) and rat (digitalis-resistant species) hearts

Comparison

Perfusion with radio-labelled digitalis… vs Normal ionic composition medium; comparison…

Design

Preclinical

Authors

SDSandip DuttaBirla Institute of Technology, MesraBMBernard H. MarksWestern Sydney University

Discussion

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Implication

Ionic effects on digitalis accumulation should not guide human dosing; leaves open species-specific mechanisms for further study.

Structured PICO

How do species differences and ionic composition affect the accumulation of polar and non-polar digitalis glycosides in isolated perfused hearts?

P
Population
Isolated perfused guinea-pig (digitalis-sensitive species) and rat (digitalis-resistant species) hearts
I
Intervention
Perfusion with radio-labelled digitalis glycosides (digoxin, digitoxin, proscillaridin, ouabain) in varying ionic compositions (low sodium, high potassium, calcium/magnesium removal)
C
Comparator
Normal ionic composition medium; comparison between species; comparison between polar and non-polar glycosides
O
Outcome
Accumulation of radio-labelled digitalis glycosides in the heart tissuesurrogate

Non-polar digitalis glycosides share the same ion-dependent accumulation mechanism as polar glycosides but also exhibit high ion-independent binding due to lipophilic membrane interactions.

Cite This Study

Dutta et al. (1972) studied this question.

synapsesocial.com/papers/6a959e8d9cc48abc53ffa7ddhttps://doi.org/10.1111/j.1476-5381.1972.tb08137.x
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Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1A COMPARISON OF THE ACCUMULATION AND RELEASE OF<sup>3</sup>H‐OUABAIN AND<sup>3</sup>H‐DIGITOXIN BY GUINEA‐PIG HEART MUSCLE1968 · 69 citations