Why the study?
Does chronic digoxin administration improve left ventricular performance in normal conscious dogs?
Population
6 healthy conscious dogs, instrumented with high-fidelity LV manometers and endocardial ultrasonic diameter…
Comparison
Chronic digoxin administration via daily… vs Control values
Design
Preclinical
Follow-up
average of 8 days
Authors
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Confirms inotropic effects in normal canine hearts; leaves open translation to human ventricular dysfunction.
Does chronic digoxin administration improve left ventricular performance in normal conscious dogs?
Chronic digoxin administration exerts a potent positive inotropic effect and improves cardiac reserve during acute pressure overloading in normal conscious dogs.
Mahler et al. (1974) studied this question.
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