Key result
Digoxin therapy had no significant effect on aerobic performance, as measured by peak oxygen uptake and anaerobic threshold, in mildly symptomatic patients with idiopathic dilated cardiomyopathy and sinus rhythm.
Why the study?
Does digoxin improve exercise capacity (peak VO2 and anaerobic threshold) in mildly symptomatic patients with idiopathic dilated cardiomyopathy and sinus rhythm?
Does digoxin improve exercise capacity (peak VO2 and anaerobic threshold) in mildly symptomatic patients with idiopathic dilated cardiomyopathy and sinus rhythm?
Absolute Event Rate: 23.8% vs 23.7%
Digoxin withdrawal and readministration did not significantly alter peak oxygen uptake or anaerobic threshold in mildly symptomatic patients with idiopathic dilated cardiomyopathy and sinus rhythm, suggesting no aerobic performance benefit in this specific population.
No takes yet. Share an insight, caveat, or question.
No change in practice warranted; hypothesis-generating and requires randomized confirmation in IDCM with sinus rhythm.
Tanabe et al. (1994) studied Idiopathic dilated cardiomyopathy and sinus rhythm (n=10). Digoxin vs. Digoxin withdrawal was evaluated on Peak oxygen uptake (peak VO2). Digoxin therapy had no significant effect on aerobic performance, as measured by peak oxygen uptake and anaerobic threshold, in mildly symptomatic patients with idiopathic dilated cardiomyopathy and sinus rhythm.
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