Why the study?
Does digoxin affect atrioventricular conduction differently in patients with intact cardiac autonomic innervation compared to those with denervated transplanted hearts?
Population
12 patients: 5 with an intact cardiac autonomic nervous system and 7 who had undergone cardiac…
Comparison
Digoxin vs Baseline and comparison between innervated…
Design
Cohort
Authors
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Effects of digoxin on AV node require intact innervation; supports autonomic mediation but leaves open direct actions in transplants.
Does digoxin affect atrioventricular conduction differently in patients with intact cardiac autonomic innervation compared to those with denervated transplanted hearts?
The electrophysiologic effects of digoxin on atrioventricular conduction in humans are most marked in the AV node and are dependent on intact cardiac autonomic innervation.
Goodman et al. (1975) studied this question.
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