Why the study?
Does intravenous digoxin affect sinus node function in patients with denervated transplanted hearts compared to those with intact autonomic innervation?
Population
13 patients: 5 with an intact cardiac autonomic nervous system and 8 with a transplanted, denervated heart.
Comparison
Digoxin 1.25 mg intravenously. vs Baseline measurements prior to digoxin…
Design
Cohort
Follow-up
45 to 60 minutes
Authors
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May induce sinoatrial exit block in denervated hearts; hypothesis-generating and should not yet change practice.
Does intravenous digoxin affect sinus node function in patients with denervated transplanted hearts compared to those with intact autonomic innervation?
Intravenous digoxin can induce sinoatrial exit block in patients with denervated, transplanted hearts despite having no significant effect on cycle length.
Goodman et al. (1975) studied this question.
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