March 1, 1990Circulation
Electrophysiological effects of adenosine in the transplanted human heart. Evidence of supersensitivity.
Why the study?
Does intravenous adenosine cause supersensitivity in the denervated donor heart compared to innervated recipient and control hearts in orthotopic cardiac transplant patients?
Population
28 orthotopic cardiac transplant patients and 9 control subjects
Comparison
Intravenous adenosine vs Recipient sinus node and control subjects
Design
Cohort
Authors
Discussion
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Member takes
Implication
May warrant caution with adenosine in transplant recipients; hypothesis-generating for arrhythmia risk and needs prospective confirmation.
Structured PICO
Does intravenous adenosine cause supersensitivity in the denervated donor heart compared to innervated recipient and control hearts in orthotopic cardiac transplant patients?
P
Population
28 orthotopic cardiac transplant patients and 9 control subjects
I
Intervention
Intravenous adenosine (incremental doses 37-112 micrograms/kg)
C
Comparator
Recipient (innervated) sinus node and control subjects
O
Outcome
Changes in sinus cycle length (SCL) (delta SCLmax%), changes in PR interval (delta PRmax%), time to peak effect (sec), and duration of electrophysiological effects (sec)surrogate
The denervated donor heart in orthotopic cardiac transplant patients demonstrates significant electrophysiological supersensitivity to exogenous adenosine compared to innervated recipient and control tissue.
Cite This Study
Ellenbogen et al. (1990) studied this question.