What question did this study set out to answer?

To assess the electrophysiological properties and intrinsic conduction characteristics of the atrioventricular system in denervated human cardiac allografts.

February 1, 1973Circulation Research

Electrophysiological Studies in the Denervated Transplanted Human Heart

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Population

3 patients who had undergone cardiac transplantation 1-2 years previously, functional class I…

Design

Case_series

Authors

DCDavid S. CannomElectrophysiology AGAnthony F. GrahamHospital for Sick Children DHDonald C. HarrisonElectrophysiology

Discussion

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Implication

Normal AV conduction persists in denervated allografts; leaves open reinnervation timing in larger cohorts.

Key Points

To assess the electrophysiological properties and intrinsic conduction characteristics of the atrioventricular system in denervated human cardiac allografts.
Evaluated 3 asymptomatic patients (NYHA functional class I) who had undergone cardiac transplantation 1 to 2 years prior.
Performed His bundle electrography during baseline sinus rhythm, rapid right atrial pacing up to 170 beats/min, and following 1–2 mg atropine administration to assess donor (AD) and recipient (AR) atrial responses.
Baseline atrium-His (AH) and His-ventricle (HV) conduction intervals were normal, with rapid atrial pacing prolonging AH intervals to an average of 205 msec and yielding an average donor recovery time of 770 msec.
The baseline donor atrial rate exceeded the recipient atrial rate by an average of 24 beats/min.
Atropine increased the recipient atrial rate by an average of 28% but caused no change in the donor atrial rate or AH conduction interval.

Structured PICO

Population

3 patients who had undergone cardiac transplantation 1-2 years previously, functional class I symptomatically, with normal hemodynamics and coronary arteriograms, in sinus rhythm with normal P-R interval and QRS configuration, not taking medications affecting the atrioventricular conduction system.

Intervention

Electrophysiological study using His bundle technique, right atrial pacing to 170 beats/min, and administration of 1-2 mg of atropine.

Outcome

Conduction characteristics of the atrioventricular conduction system (AH and HV conduction times, donor and recipient electrograms, response to pacing and atropine).surrogate

The transplanted human heart exhibits normal inherent AV node conduction delay and sinus node recovery time independent of autonomic influence, with no evidence of parasympathetic reinnervation 1-2 years post-transplant.

Cite This Study

Cannom et al. (1973) studied this question.

synapsesocial.com/papers/6a880dabaaaef52b1e4ded47 https://doi.org/10.1161/01.res.32.2.268

Topics

Heart transplantation

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Electrophysiological Studies in the Denervated Transplanted Human Heart

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Electrophysiological Studies in the Denervated Transplanted Human Heart

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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