Key result
Autonomic cardiac denervation in transplant recipients was associated with an increased incidence of ventricular arrhythmias and altered electrophysiologic responses compared to normal subjects.
Why the study?
Does autonomic denervation in cardiac transplant recipients alter basic cardiac electrophysiology, digitalis response, and arrhythmia incidence compared to normal subjects?
Population
Cardiac transplant recipients (n=47 for arrhythmia analysis) and normal subjects
Comparison
Electrophysiologic evaluation using standard… vs Normal subjects with intact autonomic innervation
Design
Cohort
Authors
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May heighten arrhythmia vigilance in transplant recipients; leaves open causal mechanisms and need for prospective confirmation.
Observational (n=47)
Does autonomic denervation in cardiac transplant recipients alter basic cardiac electrophysiology, digitalis response, and arrhythmia incidence compared to normal subjects?
The study demonstrates that while intrinsic sinus node and adrenergic receptor functions remain intact after cardiac denervation, AV node rate adaptation and digitalis effects are autonomically mediated, and denervation increases ventricular arrhythmia risk.
Mason et al. (2008) conducted an observational in Cardiac transplant recipients (n=47). Autonomic cardiac denervation (cardiac transplantation) vs. Normal subjects was evaluated on Cardiac electrophysiology, digitalis effects, and arrhythmia incidence. Autonomic cardiac denervation in transplant recipients was associated with an increased incidence of ventricular arrhythmias and altered electrophysiologic responses compared to normal subjects.
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