What question did this study set out to answer?

To evaluate donor sinus node function electrophysiologically during the first three weeks following cardiac transplantation and determine its relationship with clinical outcomes.

December 1, 1982HeartOpen Access

Sinus node function in first three weeks after cardiac transplantation.

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Why the study?

Does sinus node dysfunction in the first three weeks after cardiac transplantation predict mortality?

Population

10 patients studied from day 4 to day 24 after cardiac transplantation

Comparison

Daily assessment of donor sinus node function vs Patients without sinus node dysfunction (n=5)

Design

Cohort

Follow-up

up to 8 months

Authors

AMAlan MackintoshUniversity of Leeds DCDavid CarmichaelNorthwestern University RCR Cory-PearcePapworth Hospital

Discussion

Member takes

Implication

Post-transplant sinus node dysfunction was associated with high early mortality; hypothesis-generating for prospective validation and risk-stratification trials.

Key Points

To evaluate donor sinus node function electrophysiologically during the first three weeks following cardiac transplantation and determine its relationship with clinical outcomes.
Monitored 10 heart transplant recipients daily between postoperative day 4 and day 24 (N=10).
Assessed electrophysiological variables daily, including cardiac cycle length, atrial arrhythmias, corrected sinus node recovery time, and estimated sinoatrial conduction time.
Correlated electrophysiological findings with endomyocardial biopsy-proven rejection severity and donor organ ischaemia duration.
Five of 10 patients developed sinus node dysfunction (Group A), experiencing an 80% mortality rate (4 of 5 died within four months), whereas all five patients without dysfunction (Group B) survived for at least eight months.
Sinus node function fluctuated markedly from day to day in 9 of 10 patients, with corrected sinus node recovery time peaking between 11 and 18 days post-transplant and reaching up to 11,160 ms.
Neither sinus node dysfunction nor daily electrophysiological variations were accounted for by biopsy-detected rejection grades or allograft ischaemia times.

Structured PICO

Does sinus node dysfunction in the first three weeks after cardiac transplantation predict mortality?

Population

10 patients studied from day 4 to day 24 after cardiac transplantation

Intervention

Daily assessment of donor sinus node function (cycle length, atrial arrhythmias, corrected sinus node recovery time, and estimated sinoatrial conduction time)

Comparator

Patients without sinus node dysfunction (n=5)

Outcome

Survival/mortalityhard clinical

Sinus node dysfunction occurring soon after cardiac transplantation is a marker of poor prognosis and may lead to fatal arrhythmias.

Cite This Study

Mackintosh et al. (1982) studied this question.

synapsesocial.com/papers/6a880dffb0d802598bf4d2a8 https://doi.org/10.1136/hrt.48.6.584

Topics

Heart transplantation

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Implication

Post-transplant sinus node dysfunction was associated with high early mortality; hypothesis-generating for prospective validation and risk-stratification trials.

Sinus node function in first three weeks after cardiac transplantation.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Sinus node function in first three weeks after cardiac transplantation.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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