Key result
Administration of digoxin-specific antibodies reversed severe established digoxin toxicity in dogs, resulting in 100% survival at 72 hours compared to 0% survival in control animals.
Why the study?
Do digoxin-specific antibodies reverse toxic arrhythmias and prevent death in a canine model of severe digoxin toxicity?
Population
17 dogs with established digoxin toxicity presenting with toxic arrhythmias.
Comparison
Digoxin-specific antibodies in canine plasma… vs Control group receiving no antidigoxin antibodies.
Design
Preclinical
Follow-up
72 hours
Authors
Loading...
Should not yet change human practice; leaves open translation of digoxin-specific antibodies to clinical toxicity trials.
Do digoxin-specific antibodies reverse toxic arrhythmias and prevent death in a canine model of severe digoxin toxicity?
Absolute Event Rate: 100% vs 0%
Digoxin-specific antibodies successfully reverse severe, life-threatening digoxin-induced arrhythmias and prevent death in a canine model.
Schmidt et al. (1971) studied Digoxin toxicity (n=17). Digoxin-specific antibodies vs. Control (no serum, normal canine plasma, or non-specific rabbit antiserum) was evaluated on Survival at 72 hours. Administration of digoxin-specific antibodies reversed severe established digoxin toxicity in dogs, resulting in 100% survival at 72 hours compared to 0% survival in control animals.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: