Key result
Digoxin-specific antibodies and Fab fragments rapidly reverse digoxin toxicity, with clinical use restricted to life-threatening poisoning due to potential immune reactions.
Why the study?
Do digoxin-specific antibodies or Fab fragments reverse the effects of digitalis toxicity?
Population
In vitro models, in vivo animal models, and patients with life-threatening accidental or suicidal digoxin or…
Design
Review
Authors
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Supports restricted antidote use in severe toxicity; leaves open immunogenicity questions for wider application.
Do digoxin-specific antibodies or Fab fragments reverse the effects of digitalis toxicity?
Digoxin-specific antibodies and Fab fragments effectively reverse digitalis toxicity, offering a life-saving treatment for severe poisoning.
Larbig et al. (2008) conducted a review in Digoxin or digitoxin poisoning. Digoxin-specific antibodies (Fab fragments) was evaluated. Digoxin-specific antibodies and Fab fragments rapidly reverse digoxin toxicity, with clinical use restricted to life-threatening poisoning due to potential immune reactions.
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