Key result
Digoxin immune Fab interfered with all reported digoxin immunoassays, causing most competitive assays to yield results unrelated to true total or free digoxin concentrations.
Why the study?
Does the presence of Digoxin immune Fab (ovine) interfere with the accuracy of various digoxin immunoassays?
Population
Specimens prepared to simulate typical samples from patients treated with Digoxin immune Fab for severe…
Design
Other, Specimens distributed for analysis as unknowns
Authors
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Requires assay-specific caution interpreting post-Fab digoxin levels; leaves open optimal monitoring strategies.
Does the presence of Digoxin immune Fab (ovine) interfere with the accuracy of various digoxin immunoassays?
Digoxin immune Fab interferes significantly with most digoxin immunoassays, meaning post-treatment digoxin levels must be interpreted with extreme caution depending on the specific assay used.
Petrie M. Rainey (1989) studied Severe digitalis toxicity. Digoxin immune Fab (ovine) was evaluated on Interference with digoxin immunoassays. Digoxin immune Fab interfered with all reported digoxin immunoassays, causing most competitive assays to yield results unrelated to true total or free digoxin concentrations.
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