Key result
Polyclonal digoxin immunoassays showed significant positive or bidirectional interference from digitoxin, whereas a monoclonal chemiluminescent assay showed no significant interference.
Population
Serum sample from a patient administered digitoxin, and in vitro samples with varying digoxin and digitoxin…
Design
Other
Authors
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May warrant preferring monoclonal digoxin assays clinically; leaves open broader validation across populations.
Case Report (n=1)
Digoxin immunoassays using polyclonal antibodies can exhibit significant bidirectional interference from digitoxin, highlighting the need for highly specific monoclonal assays with cross-reactivity <0.1%.
Datta et al. (1998) conducted a case report in Therapeutic drug monitoring of digoxin/digitoxin (n=1). Digoxin immunoassays vs. Different immunoassay methods (polyclonal vs monoclonal) was evaluated on Digoxin level measurement and digitoxin interference. Polyclonal digoxin immunoassays showed significant positive or bidirectional interference from digitoxin, whereas a monoclonal chemiluminescent assay showed no significant interference.
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