Key result
Digoxin-specific antibody Fab fragments successfully treated a case of advanced digoxin toxicity.
Why the study?
Does digoxin-specific antibody Fab fragments improve outcomes in patients with advanced digoxin toxicity?
Does digoxin-specific antibody Fab fragments improve outcomes in patients with advanced digoxin toxicity?
Digoxin-specific antibody Fab fragments can successfully reverse advanced, potentially fatal digoxin toxicity.
Answers are grounded in this paper and cite their sources.
Supports Fab use in advanced digoxin toxicity; leaves open need for controlled evidence beyond single cases.
Severe digitalis toxicity is associated with a high mortality. We present a case of advanced digoxin toxicity successfully treated with digoxin-specific antibody Fab fragments, and discuss its mechanism of action. A review of the pharmacokinetics of digitalis as well as the mechanisms of cardiotoxicity and its conventional treatment is presented.
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Cooper et al. (1987) studied this question. Digoxin-specific antibody Fab fragments successfully treated a case of advanced digoxin toxicity.
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