Reversal of Advanced Digoxin Intoxication with Fab Fragments of Digoxin-Specific Antibodies

1 patient with severe digoxin intoxication (ingested 22.5 mg with suicidal intent) presenting with atrioventricular block, extreme bradycardia, and intractable hyperkalemia (serum potassium 8.7 meq/L).

Purified Fab fragments of ovine digoxin-specific antibodies (1100 mg infusion).

Reversal of advanced digoxin toxicity (return of sinus rhythm, reduction in serum potassium, and reduction in free digoxin concentrations).