Key result
Digoxin specific antibody (Fab) fragments resulted in the regression of life-threatening arrhythmias within 0.5 to 8 hours in 34 patients with severe digitalis intoxication.
Why the study?
Do digoxin specific antibody (Fab) fragments improve life-threatening arrhythmias and reduce free serum digoxin levels in patients with severe digitalis poisoning?
Observational (n=34)
Do digoxin specific antibody (Fab) fragments improve life-threatening arrhythmias and reduce free serum digoxin levels in patients with severe digitalis poisoning?
Digoxin specific antibody (Fab) fragments rapidly reverse life-threatening arrhythmias and reduce free serum digoxin in severe digitalis poisoning without notable side effects.
No takes yet. Share an insight, caveat, or question.
May support Fab use in severe digitalis toxicity; hypothesis-generating case report requiring randomized confirmation before practice change.
Smolarz et al. (1985) conducted an observational in Severe digitalis intoxication (n=34). Digoxin specific antibody (Fab) fragments was evaluated on Regression of arrhythmias and serum digoxin concentrations. Digoxin specific antibody (Fab) fragments resulted in the regression of life-threatening arrhythmias within 0.5 to 8 hours in 34 patients with severe digitalis intoxication.
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