Key result
Propranolol blunts exercise-induced skeletal muscle digoxin binding by ~59% versus saline.
Why the study?
Does propranolol reduce exercise-induced skeletal muscle digoxin binding in healthy men on maintenance digoxin?
RCT (n=10)
Single-blind
Does propranolol reduce exercise-induced skeletal muscle digoxin binding in healthy men on maintenance digoxin?
Absolute Event Rate: 12% vs 29%
Propranolol partly inhibits the exercise-induced increase in skeletal muscle digoxin binding, likely by inhibiting catecholamine-induced stimulation of Na+-K+ATPase.
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No immediate change to digoxin dosing with propranolol; leaves open clinical relevance in heart failure.
Joreteg et al. (1986) conducted an RCT in Healthy (n=10). Propranolol vs. Saline was evaluated on Increase in mean skeletal muscle digoxin concentration during exercise. Propranolol partly inhibited the exercise-induced increase in skeletal muscle digoxin binding compared to saline (12% vs 29% increase).
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