Longitudinal evaluation of serum periostin levels in patients after large-artery atherosclerotic stroke: A prospective observational study

Figures

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  Figure 1. Serum periostin levels in controls and patients at different time points. (A) Comparison of the periostin levels in 108 controls and 162 patients. (B) Comparison of periostin levels on days 1 and 6 after ischaemic stroke (134 patients). (C) Comparison of periostin levels on day 6 and the 4th week after stroke (46 patients). Student’s t-test (A) or the Wilcoxon signed-rank test (B,C) was used to assess differences. **p < 0.01. Boxes represent IQRs, with horizontal lines representing the medians, the lower and upper whiskers representing the 25th and 75th percentiles, and the error bars extending below and above the boxes representing the 10th and 90th percentiles, respectively.

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  Figure 2. Correlation between the increased periostin levels and National Institutes of Health Stroke Scale (NIHSS) scores. (A,B) Correlation between the increased periostin levels within the first 6 days and the NIHSS scores on day 1 and day 6. (C,D) Correlation between the increased periostin levels within the first 4 weeks and the NIHSS scores on day 1 and day 6. Abbreviations: NIHSS, National Institutes of Health Stroke Scale.

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  Figure 3. The increased periostin levels within the first 6 days were grouped according to the NIHSS scores. (A) NIHSS scores on day 1 after stroke. (B) NIHSS scores on day 6 after stroke. Mild stroke, NIHSS score < 8; moderate-to-severe stroke, NIHSS score ≥8. Differences were compared using the Mann-Whitney U test. *p < 0.05, **p < 0.01. Boxes represent IQRs, with horizontal lines representing the medians, the lower and upper whiskers representing the 25th and 75th percentiles, and the error bars extending below and above the boxes represent the 10th and 90th percentiles, respectively.

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  Figure 4. Study flow chart. Abbreviations: LAA stroke, large-artery atherosclerotic stroke; NIHSS, National Institutes of Health Stroke Scale; mRS, modified Rankin Scale.