Genetic cloning study reveals three distinct genes within the manXYZ locus of Escherichia coli, indicating specialized roles in mannose transport and bacteriophage infection.
The pel/ptsM locus codes for two apparently unrelated activities: transport of mannose by the phosphoenolpyruvate-dependent phosphotransferase system (PTS) and penetration of bacteriophage λ-DNA. This locus is known to consist of at least two genes, ptsL (manX) and pel/ptsM (manYZ). In this paper we present the cloning and analysis of the manXYZ locus. Subcloning and complementation analysis of the different fragments suggest that the locus contains 3 separate genes manX, manY and manZ and that the corresponding gene products are involved in mannose uptake. In addition, manY codes for the Pel function, necessary for penetration of λ-DNA.
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Saris et al. (1987) studied this question.
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