Key result
Sulprostone infusion reduces plasma renin activity by up to ~64% versus controls.
Why the study?
The mechanisms and function of the renin-angiotensin system in pregnancy are still rather poorly known, motivating investigation of plasma renin activity changes during pregnancy termination induced by sulprostone.
Does sulprostone infusion affect plasma renin activity and cAMP levels in women undergoing termination of pregnancy?
Does sulprostone infusion affect plasma renin activity and cAMP levels in women undergoing termination of pregnancy?
p-value: p=<0.001
Sulprostone infusion during termination of pregnancy causes a rapid, transient decrease in plasma renin activity, providing insight into the renin-angiotensin system in pregnancy.
Sulprostone-associated renin suppression may inform RAS physiology in pregnancy; leaves open cAMP effects and clinical relevance.
Plasma renin activity (PRA), plasma concentrations of cyclic adenosine-3',5'-monophosphate (cAMP) and the serum levels of oestradiol, progesterone, chorionic gonadotrophin, potassium, sodium and calcium were estimated in connection with termination of pregnancy induced in 23 women by sulprostone, a derivative of prostaglandin E2. A rapid decrease in PRA was observed during and after infusion of 1000 micrograms or 1500 micrograms sulprostone. PRA returned to the initial values at 24 h after drug administration. The lowest levels of PRA were 36% and 51% of the initial values (P less than 0.001) in the two drug concentration groups. No significant changes were observed in the control group. The value for plasma cAMP did not correspond completely to the changes in PRA. Serum concentrations of oestradiol, progesterone and chorionic gonadotrophin showed a gradual decrease during drug administration. The changes in serum potassium, sodium and calcium were minimal. The decrease in PRA associated with sulprostone is very surprising. Our finding elucidates in part the still rather poorly known mechanisms and function of renin-angiotensin system in pregnancy.
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Saarikoski et al. (1987) studied Termination of pregnancy (n=23). Sulprostone vs. Control group was evaluated on Plasma renin activity (PRA) (p=<0.001). Sulprostone infusion for termination of pregnancy significantly decreased plasma renin activity to 36% and 51% of initial values (P<0.001) compared to controls.
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