What question did this study set out to answer?

To examine whether bacteria-derived extracellular vesicles are excreted in urine and evaluate differences in their metagenomic composition between pregnant and non-pregnant women, as well as between term and preterm deliveries.

February 5, 2016Experimental & Molecular MedicineOpen Access

16S rRNA gene-based metagenomic analysis reveals differences in bacteria-derived extracellular vesicles in the urine of pregnant and non-pregnant women

View Full Paper

Ask AI

Bookmark

To examine whether bacteria-derived extracellular vesicles are excreted in urine and evaluate differences in their metagenomic composition between pregnant and non-pregnant women, as well as between term and preterm deliveries.
Enrolled 74 pregnant women and 73 non-pregnant women at two university hospitals in South Korea.
Isolated urinary extracellular vesicles using differential centrifugation and extracted bacterial DNA.
Conducted 16S rRNA gene sequencing targeting the V1–V3 region using high-throughput 454 pyrosequencing.
Taxonomic profiles differed significantly across 13 taxa, with Bacillus spp. extracellular vesicles enriched in pregnant women compared with non-pregnant women (45.61% vs 0.12%).
Pseudomonas spp. extracellular vesicles were significantly more predominant in non-pregnant women than in pregnant women (13.2% vs 4.09%).
Extracellular vesicles derived from Ureaplasma spp. and the family Veillonellaceae (including Megasphaera spp.) were enriched in the urine of women with preterm delivery compared to normal full-term delivery.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Observational study reveals distinct urinary bacterial extracellular vesicle profiles in pregnant women, suggesting specific microbial vesicles support pregnancy maintenance.

Cite This Study

Yoo et al. (2016) studied this question.

synapsesocial.com/papers/6aabc614ef52b0402e16e267 https://doi.org/10.1038/emm.2015.110

View Full Paper

Ask AI

Bookmark

Implication

Observational study reveals distinct urinary bacterial extracellular vesicle profiles in pregnant women, suggesting specific microbial vesicles support pregnancy maintenance.

16S rRNA gene-based metagenomic analysis reveals differences in bacteria-derived extracellular vesicles in the urine of pregnant and non-pregnant women

Key Points

Discussion

Implication

Cite This Study

16S rRNA gene-based metagenomic analysis reveals differences in bacteria-derived extracellular vesicles in the urine of pregnant and non-pregnant women

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider