Key result
Stable COPD linked to subclinical peripheral nerve impairment and delayed conduction vs healthy controls.
Why the study?
Chronic obstructive pulmonary disease is associated with neurological involvements including peripheral nervous system affection, but subclinical peripheral nerve involvement in stable COPD patients was not well characterized.
Do patients with stable COPD have subclinical peripheral nervous system affection compared to healthy controls?
Case-Control (n=70)
No
Do patients with stable COPD have subclinical peripheral nervous system affection compared to healthy controls?
Absolute Event Rate: 4.37% vs 3.68%
p-value: p=<0.001
Patients with stable COPD exhibit subclinical peripheral nervous system affection, primarily demyelinating, which warrants neurophysiological observation.
May warrant neurophysiological monitoring in stable COPD; hypothesis-generating and requires prospective validation.
Background Chronic obstructive pulmonary disease (COPD) is accompanied by substantial systemic dysregulations that comprise systemic inflammation and neurohormonal activation in addition to many neurological involvements, such as cerebrovascular diseases, polyneuropathies, motor neuron diseases, and cognitive impairment has been described in COPD patients. The aim of the current work was to detect the subclinical affection of the peripheral nervous system in patients with stable COPD. Results Forty COPD patients and 30 subjects as healthy control were enrolled. All included subjects were submitted to complete medical history, clinical evaluations, investigations in the form of; arterial blood gases, spirometry, in addition to nerve conduction study. The patients with COPD were classified according to GOLD criteria for severity in grade I in 7.5% grade II in 62.5%, grade III in 20%, and grade IV in 10%. The results show a statistically significant increase in distal latency and a statistically significant decrease of amplitude and conduction velocity in patients with COPD when compared to the examined nerves of control group. The demyelinating nerve affection was the most common. Conclusion In COPD patients the peripheral nervous system could be affected subclinically once the severity of COPD increased and the patient should be neurophysiologically observed for early recognition of peripheral nervous system affection.
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Ali et al. (2021) conducted a case-control in Chronic obstructive pulmonary disease (COPD) (n=70). Chronic obstructive pulmonary disease (COPD) vs. Healthy non-smoker controls was evaluated on Right median nerve distal latency (ms) (p=<0.001). Stable COPD is associated with subclinical peripheral nervous system affection, evidenced by significantly increased distal latency and decreased amplitude and conduction velocity compared to healthy controls.
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