Key result
Adrenocortical carcinoma genotyping indicates DNA damage repair alterations could open new avenues for drug repurposing.
Why the study?
Comprehensive molecular characterization of adrenocortical carcinoma is expanding potential prognostic and therapeutic targets, requiring critical review of recent genotyping literature.
Systematic Review (n=423)
Genomic profiling of adrenocortical carcinoma identifies potential new therapeutic targets, particularly in DNA damage repair genes and promoter hypermethylation, for drug repurposing.
Should not yet change adrenocortical carcinoma management; hypothesis-generating for DNA repair and methylation-targeted repurposing trials.
PURPOSE OF REVIEW: comprehensive molecular characterization of adrenocortical carcinoma (ACC) through next-generation sequencing and bioinformatics analyses is expanding the number of targets with potential prognostic and therapeutic value. We performed a critical review of recent published literature on genotyping of ACC. RECENT FINDINGS: 423 studies were published between 2019 and 2021. After manual curation we summarized selected evidence in two thematic areas: germline deoxyribonucleic acid (DNA) variations, genomic alterations and prognosis. SUMMARY: the evolving genomic landscape of ACC requires target validation in terms of prognostic and predictive value within scientific consortia. Although the existing multiple driver genes are difficult targets in the perspective of precision oncology, alterations in DNA damage repair genes or in promoter hypermethylation could open new venues for repurposing of existing drugs in ACC.
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A 2021 study conducted a systematic review in adrenocortical carcinoma (n=423). Molecular genotyping was evaluated. A review of 423 studies on adrenocortical carcinoma genotyping indicates that alterations in DNA damage repair genes or promoter hypermethylation could open new venues for drug repurposing.
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