Key result
Vitamin D deficiency in rural COPD is linked to ~130% higher odds of worse HRQoL.
Why the study?
Data on vitamin D status and its associations with health outcomes in rural COPD cohorts are limited.
Is Vitamin D deficiency associated with worse health status in older patients with COPD?
Cross-Sectional (n=138)
Is Vitamin D deficiency associated with worse health status in older patients with COPD?
Vitamin D deficiency is prevalent in rural COPD patients and is associated with worse health-related quality of life, depression, and poor sleep quality.
Answers are grounded in this paper and cite their sources.
Vitamin D deficiency may link to poorer health status in rural COPD; leaves open need for prospective trials before screening or supplementation.
BACKGROUND & AIMS: While low vitamin D levels are common in Chronic Obstructive Pulmonary Disease (COPD) and have been associated with various adverse COPD-related outcomes, data on vitamin D status in rural COPD cohorts is limited. Therefore, the present study aimed to assess the prevalence of Vitamin D deficiency among patients with COPD living in rural areas and explore its potential association on the overall health status. METHODS: This cross-sectional study included 138 participants >40 years with COPD from the prospective "COlaborative care vs usual CARE in primary care patients with COPD" (COCARE) study. Sociodemographic characteristics, medical history, patient's health-related quality of life (HRQoL) with the COPD Assessment Test (CAT), fatigue with the Fatigue Severity Scale (FSS), phycological parameters with Patient Health Questionnaire-9 (PHQ-9) and General Anxiety Disorder-7 (GAD-7), sleep disorders with the COPD and Asthma Sleep Impact Scale (CASIS), Athens Insomnia Scale (AIS) and the Epworth Sleepiness Scale (ESS) were collected. Vitamin D deficiency was defined as levels of 25-hydroxy (OH)-Vitamin D below 20 ng/mL. Multiple logistic regression analysis was conducted to test for associations of Vitamin D deficiency with CAT, FSS, PHQ-9, GAD-7, CASIS, AIS, and ESS, adjusting for age, gender, smoking status, comorbidities, and seasonality. Moreover, 33 % of the participants had Vitamin D deficiency. Vitamin D deficiency increased the odds for worse HRQoL (CAT≥10 OR: 2.3, CI: 0.9-6.4, p = 0.008), greater fatigue severity (FSS, OR: 1.2, CI: 0.4-3.1, p = 0.756), more depressive (PHQ-9≥5, OR: 2.9, CI: 1.1-7.4, p = 0.024), anxiety (GAD-7, OR: 0.8, CI: 0.3-2.1, p = 0.592) and insomnia symptoms (AIS score OR: 1.1, CI: 0.7-5, p = 0.29), excessive daytime sleepiness (ESS, OR: 1.1, CI: 0.7-5, p = 0.29), and lower sleep quality (CASIS OR: 2.5, CI: 0.9-6.5, p = 0.006). CONCLUSION: In conclusion, our findings indicate that Vitamin D deficiency is positively associated with numerous negative health outcomes of patients with COPD, including worse HRQoL, fatigue, depression, anxiety and sleep disorders. However, further research is needed to determine the role of Vitamin D in the health status of these patients.
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Bouloukaki et al. (2025) conducted a cross-sectional in Chronic Obstructive Pulmonary Disease (COPD) (n=138). Vitamin D deficiency vs. Normal Vitamin D levels was evaluated on worse HRQoL (CAT≥10) (OR 2.3, 95% CI 0.9-6.4, p=0.008). Vitamin D deficiency in rural COPD patients was associated with worse health-related quality of life (OR 2.3; 95% CI 0.9-6.4; p=0.008) and more depressive symptoms.
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