Key result
Advanced MRI identifies regional brain abnormalities linked to cognitive dysfunction in patients with SLE.
Why the study?
Cognitive dysfunction is highly prevalent in systemic lupus erythematosus, yet the underlying mechanisms remain poorly understood.
Do advanced structural and diffusion MRI metrics correlate with cognitive dysfunction in patients with systemic lupus erythematosus?
Systematic Review
Do advanced structural and diffusion MRI metrics correlate with cognitive dysfunction in patients with systemic lupus erythematosus?
Advanced structural and diffusion MRI can identify regional brain abnormalities associated with cognitive dysfunction in patients with systemic lupus erythematosus, highlighting the hippocampus, corpus callosum, and frontal cortex as key affected areas.
May aid neuroimaging assessment of cognitive dysfunction in SLE; extends observational evidence to specific regions but requires prospective validation.
Background Cognitive dysfunction (CD) is highly prevalent in systemic lupus erythematosus (SLE), yet the underlying mechanisms are poorly understood. Neuroimaging utilizing advanced magnetic resonance imaging (MRI) metrics may yield mechanistic insights. We conducted a systematic review of neuroimaging studies to investigate the relationship between structural and diffusion MRI metrics and CD in SLE. Methods We systematically searched several databases between January 2000 and October 2023 according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Retrospective, and prospective studies were screened for search criteria keywords (including structural or diffusion MRI, cognitive function, and SLE) to identify peer-reviewed articles reporting advanced structural MRI metrics and evaluating CD in human patients with SLE. Results Eighteen studies (8 structural MRI, 9 diffusion MRI, and 1 with both modalities) were included; sample sizes ranged from 11 to 120 participants with SLE. Neurocognitive assessments and neuroimaging techniques, parameters, and processing differed across articles. The most frequently affected cognitive domains were memory, psychomotor speed, and attention; while abnormal structural and/or diffusion MRI metrics were found more consistently in the hippocampus, corpus callosum, and frontal cortex of patients with SLE, with and without clinically diagnosed CNS involvement. Conclusion Advanced structural MRI analysis can identify total and regional brain abnormalities associated with CD in patients with SLE, with potential to enhance clinical assessment. Future collaborative, longitudinal studies of neuroimaging in SLE are needed to better characterize CD, with focus on harmonized neurocognitive assessments, neuroimaging acquisitions and post-processing analyses, and improved clinical characterization of SLE cohorts.
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Cabrera et al. (2024) conducted a systematic review in Systemic Lupus Erythematosus. Systemic Lupus Erythematosus vs. Healthy controls was evaluated on Relationship between structural and diffusion MRI metrics and cognitive dysfunction. Advanced structural and diffusion MRI identified abnormalities in the hippocampus, corpus callosum, and frontal cortex of patients with SLE that were associated with cognitive dysfunction.
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