Key result
NAFLD is linked to ~2.7-fold higher CAD likelihood in patients with T2DM.
Why the study?
Non-alcoholic fatty liver disease (NAFLD) is common in Type 2 diabetes mellitus and its correlation with coronary artery disease (CAD) requires clarification.
Does the presence of NAFLD correlate with an increased prevalence of CAD in patients with Type 2 diabetes mellitus?
Cross-Sectional (n=114)
No
Does the presence of NAFLD correlate with an increased prevalence of CAD in patients with Type 2 diabetes mellitus?
Odds Ratio: 2.7
Absolute Event Rate: 72.46% vs 52.63%
p-value: p=0.002
In patients with Type 2 diabetes, NAFLD is highly prevalent and serves as an independent predictor for the presence of coronary artery disease.
Association of NAFLD with CAD in T2DM is hypothesis-generating; does not support screening or practice change.
Background: Non-alcoholic fatty liver disease (NAFLD) is a common association of Type 2 diabetes mellitus and diabetes mellitus is a leading risk factor for coronary artery disease (CAD). This study aims at estimating the prevalence of NAFLD by ultrasonography and to correlate NAFLD with CAD in a group of patients with Type 2 DM.Methods: Consecutive patients of Type 2 diabetes fulfilling the inclusion criteria were recruited. Clinical and biochemical parameters were recorded. NAFLD was diagnosed by ultrasonography.Results: The prevalence of NAFLD was 41.2% in the study group (n=114) and was higher in females. Prevalence of NAFLD in the younger age group was significantly higher than that in the older age group. Elevated liver enzymes, elevated HbA1C, duration of diabetes, obesity, acanthosis nigricans and metabolic syndrome were all significantly associated with NAFLD. CAD was significantly higher in the NAFLD subgroup (72.46%) compared to the non-NAFLD subgroup (52.63%) (p=0.001). Using binary logistic regression analysis, it was found that NAFLD is an independent predictor of CAD (p=0.002).Conclusions: NAFLD is extremely common in people with Type 2 diabetes and is associated with a higher prevalence of CAD.NAFLD is an independent risk factor for development of CAD. Thus, identification of NAFLD in diabetics might help in predicting the risk of CAD and to adopt the necessary preventive strategy.
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Prabhakar et al. (2017) conducted a cross-sectional in Type 2 diabetes mellitus (n=114). Non-alcoholic fatty liver disease (NAFLD) vs. Without NAFLD was evaluated on Coronary artery disease (CAD) (OR 2.7, p=0.002). Non-alcoholic fatty liver disease was independently associated with a 2.7-fold increased likelihood of coronary artery disease in patients with type 2 diabetes mellitus.
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