Key result
Paternal diabetes history is linked to ~170% higher early-onset T2D risk, with males diagnosed younger.
Why the study?
The correlation between different diabetic family history and gender with the diagnosed age of type 2 diabetes mellitus was not well understood in the Chinese population.
Cross-Sectional (n=3,725)
No
Odds Ratio: 2.7 (95% CI 2.058–3.543)
p-value: p=<0.001
Male gender and a paternal family history of diabetes are associated with an earlier age of onset for type 2 diabetes mellitus in a Chinese cohort.
Background: To investigate the correlation between different diabetic family history and gender with diagnosed age of type 2 diabetes mellitus(T2DM).Methods: To register the newly diagnosed T2DM patients who were admitted to the diabetes identification center of our hospital from October 2017 to June 2020. According to whether the age of diagnosis is more than 40 years old, patients were divided into two groups (early-onset T2DM and late-onset T2DM). In the study,the DM family history was divided into five types: (a)Father DM:Only the father had diabetes in both parents;(b)Mother DM:Only the mother had diabetes in both parents;(c)Both parents DM,Both parents have DM;(d)other family history of DM (without father or mother with DM) and (e)without family history of DM.The diagnosed age with different genders and diabetic family history is compared.Multivariate logistic regression analysis was used to investigate the correlation factors of early-onset T2DM.Results: 3725 patients completed the survey. There were 589 patients (15.8%) with early-onset T2DM, and2469 patients (66.3%) had diabetic family history. The T2DM diagnosed age in male was lower than that in female(51.7 ± 11.2vs54.0 ± 10.2,t = -6.283, p<0.001).The result was also reflected in different DM family history(with Both parents DM,46.7±11.1vs48.5±10.3,t = -1.105, p=0.271;with Father DM,46.8±10.8vs49.8±11.3,t=-2.825,p=0.005;with Mother DM,50.4±10.6vs52.3±10.2,t=-2.342,p=0.019;with other DM familiy history,54.0±10.8vs55.7±9.5,t=-2.652,p=0.008;with NO DM familiy history,53.0±11.0vs55.9±9.3,t=-4.738,p<0.001).T2DM diagnosed age with both parents DM(47.5±11.0) and father DM(47.9±11.1) family history Conclusion: Patients with early-onset T2DM tend to have more obvious DM family history in China. This survey shows that the parent DM family history especially father diabetes family history, male patients are diagnosed T2DM earlier.Drinking history was negatively correlated with the early-onset T2DM in male patients.We need more aggressive screening for diabetes in children with a family history of diabetes, especially in men.
No takes yet. Share an insight, caveat, or question.
Hao et al. (2020) conducted a cross-sectional in Type 2 diabetes mellitus (n=3,725). Father history of diabetes mellitus vs. No family history of diabetes mellitus was evaluated on Early-onset type 2 diabetes mellitus (diagnosis age < 40 years) (OR 2.700, 95% CI 2.058-3.543, p=<0.001). A paternal family history of diabetes was strongly associated with early-onset type 2 diabetes (OR 2.700), and male patients were diagnosed at a significantly younger age than female patients.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: