Key result
Mouse supraclavicular brown adipose tissue has a heart-associated origin, making it a potentially better translational model for human thermogenic fat than interscapular depots.
The discovery of a heart-associated origin for mouse supraclavicular BAT challenges the traditional use of interscapular BAT in research and may improve translational models for human thermogenic fat.
Ran et al. identify a heart-associated origin of mouse supraclavicular brown adipose tissue (BAT). Their findings challenge the dominance of interscapular BAT in mouse research and suggest that anatomically corresponding depots may better inform translation to human thermogenic fat.
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SHI et al. (2026) studied this question. Mouse supraclavicular brown adipose tissue has a heart-associated origin, making it a potentially better translational model for human thermogenic fat than interscapular depots.
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