Key result
Nonspecific connective tissue disorder traits like MVP are linked to local longitudinal LV strain.
Why the study?
Early non-invasive diagnosis of structural changes in the heart is important for preventing dangerous rhythm disorders in young patients with nonspecific connective tissue disorder (NCTD).
Observational
Effect estimate: r1 = 0.519
p-value: p=0.003
Phenotypic features of nonspecific connective tissue disorder, such as chest deformity and mitral valve prolapse, are associated with altered myocardial strain and elevated NT-proBNP in patients with arrhythmias, suggesting early myocardial remodeling.
May indicate early remodeling in arrhythmic patients with mitral valve prolapse; hypothesis-generating and should not yet change practice.
Early non-invasive diagnosis of structural changes in the heart plays an important role in optimizing approaches to preventing dangerous rhythm disorders at a young age.Aim: To study the phenotypic features of nonspecifi c connective tissue disorder (NCTD) in relation to the myocardial strain and the level of N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with cardiac arrhythmias and NCTD.Results. There was an association between a local longitudinal left ventricular (LV) strain and pectus excavatum (r1 = 0.234, p = 0.008), joint hypermobility syndrome (r1 = 0.406, p = 0.026), spinal scoliosis (r1 = 0.266, p = 0.003), mitral valve prolapse (MVP) (r1 = 0.519, p = 0.003), diagnostic threshold of NCTD (r1 = 0.395, p = 0.031) in patients with arrhythmias and NCTD;there was an inverse weak to moderate association of body mass index (BMI) and myocardial strain in a number of LV segments. There was a signifi cant relationship between NT-proBNP and diagnostic threshold of NCTD (r1 = 0.496, p = 0.001), mitral valve prolapse (r1 = 0.469, p = 0.002).Conclusion. Chest deformity, spinal scoliosis, joint hypermobility, mitral valve prolapse and BMI decrease in patients with arrhythmic syndrome and NCTD are associated with the myocardial strain and NT-proBNP level that can be used for the early identifi cation of myocardial remodeling in this patient cohort.
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Логинова et al. (2024) conducted an observational in Cardiac arrhythmias and nonspecific connective tissue disorder (NCTD). Phenotypic features of nonspecific connective tissue disorder was evaluated on Myocardial strain and NT-proBNP level (r1 = 0.519, p=0.003). Phenotypic features of nonspecific connective tissue disorder, such as mitral valve prolapse, were significantly associated with local longitudinal left ventricular strain (r=0.519, p=0.003).
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