Key result
Lower HDL in Fontan adults is linked to ~37% higher risk of CV hospitalization or death.
Why the study?
Patients with a Fontan circulation may have hypocholesterolemia secondary to Fontan-associated liver disease or inflammation, but circulating lipid profiles and their clinical associations are not well characterized.
Cohort (n=245)
Hazard Ratio: 1.37 (95% CI 1.04–1.81)
p-value: p=0.03
Adults with a Fontan circulation have significantly lower cholesterol levels than healthy controls, and lower HDL-C is associated with an increased risk of cardiovascular hospitalization or death, potentially driven by inflammation.
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Supports HDL-C as a prognostic marker in Fontan adults; leaves open whether HDL-targeted interventions improve outcomes.
A 2021 study conducted a cohort in Fontan circulation (n=245). Lower high-density lipoprotein cholesterol vs. Higher high-density lipoprotein cholesterol was evaluated on Combined outcome of nonelective cardiovascular hospitalization or death (HR 1.37, 95% CI 1.04-1.81, p=0.03). Lower HDL cholesterol in adults with a Fontan circulation was associated with increased risk of nonelective cardiovascular hospitalization or death (HR 1.37; 95% CI 1.04-1.81; P=0.03).
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