Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 1, 1990British Journal of Clinical PharmacologyOpen Access

In vitro metabolism of the biguanide antimalarials in human liver microsomes: evidence for a role of the mephenytoin hydroxylase (P450 MP) enzyme.

View Full Paper
Ask AI
Bookmark
Share

Authors

NHNuala A. HelsbyUniversity of AucklandSWStephen A. WardLiverpool School of Tropical MedicineRHRE HowellsUniversity of Liverpool

Discussion

Loading...

Member takes

Implication

Key Points

Key points are not available for this paper at this time.

Cite This Study

Helsby et al. (1990) studied this question.

synapsesocial.com/papers/6aabd491e246da466683500dhttps://doi.org/10.1111/j.1365-2125.1990.tb03777.x
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Plasma Paludrine Levels – Some Observations in Commonwealth Troops in The Far East 19701985 · 10 citations
  2. 2PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT1951 · 318,705 citations
  3. 3The Determination of Enzyme Dissociation Constants1934 · 12,130 citations
  4. 4Contribution of Environmental Factors to Variability in Human Drug Metabolism1979 · 34 citations
  5. 5Genetic polymorphism of human cytochrome P-450 (S)-mephenytoin 4-hydroxylase. Studies with human autoantibodies suggest a functionally altered cytochrome P-450 isozyme as cause of the genetic deficiency1987 · 60 citations