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July 8, 2020Experimental Biology and MedicineOpen Access

High atherogenic index of plasma and cardiovascular risk factors among Ghanaian breast cancer patients

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Key result

Atherogenic index of plasma is linked to ~10-fold higher breast cancer odds in Ghanaian women.

  • OR 10.44
  • P<0.001
  • n=104

Why the study?

Comorbidities negatively impact breast cancer prognosis, especially in developing countries where cases present at advanced stages, but the relationship between AIP and cardiovascular risk factors in Ghanaian breast cancer patients is not well characterized.

Is breast cancer associated with elevated atherogenic index of plasma and cardiovascular risk factors in Ghanaian women?

Population

52 Ghanaian breast cancer patients and 52 age-matched healthy controls

Comparison

Breast cancer patients vs age-matched healthy controls

Design

Case-control study

Authors

ETEmmanuel Ayitey TagoeUniversity of GhanaEDEric Dwamena-AkotoJNJosephine NsafulUniversity of Ghana

Discussion

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Implication

Should not yet change practice or screening; leaves open causal links and need for prospective validation in African populations.

Study Design

Type

Case-Control (n=104)

Structured PICO

Is breast cancer associated with elevated atherogenic index of plasma and cardiovascular risk factors in Ghanaian women?

P
Population
104 Ghanaian women (52 with breast cancer and 52 age-matched healthy controls) evaluated for atherogenic index of plasma and cardiovascular risk factors.
E
Exposure
Breast cancer (exposure)
C
Comparator
Age-matched healthy controls
O
Outcome
Atherogenic index of plasma (AIP) and cardiovascular risk factors (blood pressure, lipid profile, obesity)surrogate

Main Result

Odds Ratio: 10.44

p-value: p=<0.001

Ghanaian women with breast cancer have significantly elevated atherogenic index of plasma and cardiovascular risk factors compared to healthy controls.

Cite This Study

Tagoe et al. (2020) conducted a case-control in Breast cancer (n=104). Atherogenic index of plasma (AIP) vs. Healthy controls was evaluated on Breast cancer (OR 10.44, p=<0.001). Atherogenic index of plasma was significantly associated with breast cancer among Ghanaian women (OR 10.44, P<0.001).

synapsesocial.com/papers/6aabd69fcb3049f051c54a05https://doi.org/10.1177/1535370220940992

Topics

Women and heart disease
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Predictive Utility of Atherogenic Index of Plasma in Carcinoma Breast Cases in Correlation with Oxidative Stress, Immuno-biomarkers and Body Mass Index2026
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  3. 3Atherogenic index of plasma and risk of cardiovascular disease among Cameroonian postmenopausal women2016 · 82 citations
  4. 4Lipid Profile and Atherogenic Risk Assessment in Nigerian Breast Cancer Patients – A Cross-Sectional Study2024 · 3 citations
  5. 5Atherogenic index of plasma and its cardiovascular risk factor correlates among patients with type 2 diabetes in Uganda2023 · 31 citations