Key result
Beta-adrenergic blocking agents further decrease cardiac output and do not normalize haemodynamics in essential hypertension, but achieve satisfactory blood-pressure reduction.
Why the study?
The haemodynamic effects of beta-adrenergic blocking agents in early and established essential hypertension, including differences by beta 1-selectivity and intrinsic activity, were not fully characterized.
What are the haemodynamic effects of beta-receptor blockade in patients with essential hypertension?
What are the haemodynamic effects of beta-receptor blockade in patients with essential hypertension?
Beta-blockers effectively reduce blood pressure in essential hypertension despite further decreasing cardiac output and not normalizing underlying haemodynamics.
Supports beta-blocker use for BP control despite reduced cardiac output; leaves open long-term hemodynamic and outcome effects.
In early essential hypertension, an increase in cardiac output (CO) is seen in about two-thirds of the patients. In established essential hypertension, CO is usually normal or subnormal, while total peripheral resistance (TPR) is increased. Treatment with beta-adrenergic blocking agents accentuates these haemodynamic changes; in particular CO is further decreased. Comparison of the effects of beta-blockers with and without beta 1-selectivity and intrinsic activity reveals slight differences in the haemodynamic responses. Although none of the beta-blockers normalizes the haemodynamics, satisfactory blood-pressure reduction may be achieved at rest and during exercise with minimal side effects.
No takes yet. Share an insight, caveat, or question.
Henrik Jensen (1982) conducted a review in essential hypertension. beta-adrenergic blocking agents was evaluated on haemodynamic changes. Beta-adrenergic blocking agents further decrease cardiac output and do not normalize haemodynamics in essential hypertension, but achieve satisfactory blood-pressure reduction.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: