What question did this study set out to answer?

To characterize long-term CD4 cell dynamics and clinical outcomes over a 15-year period in antiretroviral-naïve HIV controllers with suppressed or low-level viremia.

April 21, 2011PLoS ONEOpen Access

CD4 Dynamics over a 15 Year-Period among HIV Controllers Enrolled in the ANRS French Observatory

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To characterize long-term CD4 cell dynamics and clinical outcomes over a 15-year period in antiretroviral-naïve HIV controllers with suppressed or low-level viremia.
Evaluated 81 asymptomatic, antiretroviral-naïve HIV controllers infected for ≥10 years with HIV-RNA <400 copies/mL in >90% of samples within the ANRS French Observatory.
Categorized participants by viral load (VL) profiles: no blips (always below assay detection limits), rare blips (<50% of samples above detection), and frequent blips (>50% of samples above detection).
Analyzed CD4 count slopes from diagnosis using mixed-effect linear models and tracked clinical, immunological, and virological outcomes.
CD4 counts remained stable after diagnosis in the no-blip group, but declined significantly in the rare blip (-0.26√CD4/mm³/year) and frequent blip (-0.28√CD4/mm³/year) groups.
Zero clinical, immunological, or virological progression events occurred in the no-blip group, compared with three immunological/virological events and four cancers observed across the blip subgroups.
HIV controllers constituted 0.31% of French hospital-managed patients, showing an overrepresentation of intravenous drug users (31%) and underrepresentation of homosexual men (26%).

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Implication

Cohort study reveals CD4 cell decline and clinical events linked to viral blips in HIV controllers, suggesting persistent low-level replication drives disease progression.

Cite This Study

Boufassa et al. (2011) studied this question.

synapsesocial.com/papers/6aabdcc5dec6679171c54d79 https://doi.org/10.1371/journal.pone.0018726

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Implication

Cohort study reveals CD4 cell decline and clinical events linked to viral blips in HIV controllers, suggesting persistent low-level replication drives disease progression.

CD4 Dynamics over a 15 Year-Period among HIV Controllers Enrolled in the ANRS French Observatory

Key Points

Discussion

Implication

Cite This Study

CD4 Dynamics over a 15 Year-Period among HIV Controllers Enrolled in the ANRS French Observatory

Key Points

Discussion

Implication

Cite This Study

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