Key result
Isotretinoin links to acute pancreatitis despite normal triglycerides in a rare idiosyncratic reaction.
Why the study?
Pancreatitis is a well-known but rare side effect of isotretinoin with proposed mechanisms including hypertriglyceridemia and idiosyncratic reaction.
Does isotretinoin cause pancreatitis in a young man?
Case Report (n=1)
Does isotretinoin cause pancreatitis in a young man?
Isotretinoin can cause pancreatitis through an idiosyncratic reaction, presenting with elevated lipase even without CT evidence of inflammation.
Answers are grounded in this paper and cite their sources.
Case of isotretinoin-associated pancreatitis is hypothesis-generating; leaves open prospective studies on incidence and monitoring.
Isotretinoin is a frequently prescribed medication for severe nodulocystic acne. It is also used in higher doses and other forms to treat some carcinomas. Pancreatitis remains a well-known but rare side effect of this medication. Two proposed mechanisms for pancreatitis are hypertriglyceridemia induced and idiosyncratic reaction. Here, we present a case of a young man who presented for the evaluation of abdominal pain. His blood work showed elevated lipase levels but computed tomography (CT) of the abdomen did not show any pancreatic inflammation.
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Atiq et al. (2019) conducted a case report in Acute pancreatitis (n=1). Isotretinoin was evaluated on Development of acute pancreatitis. Isotretinoin use was associated with the development of acute pancreatitis in a 29-year-old male with normal triglyceride levels, indicating a rare idiosyncratic reaction.
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