Background: Osteoarthritis (OA) of knee is one of the most common debilitating conditions associated with pain and limitation in daily living activities which negatively affect quality-of-life.It is a disease of the entire joint, involving not only the joint lining but also cartilage, ligaments, and bone.It is characterized by breakdown of the cartilage, bony changes of the joints, deterioration of tendons and ligaments, and various degrees of inflammation of the synovium.Aim of the Work: To discuss the incidence and updates in Pathophysiology of Osteoarthritis (OA) of knee and demonstrate updates in management to solve this problem. Study Design: Narrative review article.Conclusion: The current review revealed that Osteoarthritis (OA) of knee joint has multi mechanism and increases the risk of complications bed redden as such, accounts for burden on economics budget.
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