Evaluation of Adequate Time for Intravenous Cannulation in Children during Sevoflurane Induction

Background: The early placement of an intravenous (iv) cannulation in children anesthetized with halothane has been shown safe and acceptable compared with later placement.However, there's not well known with sevoflurane use [2].Aim: The aim of our study is to determine whether one should make iv attempts during the early induction period (at 60seconds) or lately (90 or 120 s).Methods: We conducted a prospective randomized study, after obtaining Institutional review board approval, which didn't require written parental consent.The Trial registration was (Protocol ID : 0925-0586 ; Clinical trial.govID : NCT03851692).Children age 1-12 years, undergoing elective general anesthesia via an inhalation induction were randomized to one of three groups of 30 patients each one, for iv placement, either 60s (group E), 90 or 120 s (group L) following loss of lid reflex.Results: The study groups were comparable in term of age (p=0.48),Sex, weight and ASA (p=0.33).Movement on iv placement happened in 12 cases of group E but any case in group L (p<0.0001).There was no case of laryngospasm in each group.The iv placement was better at first attempt in 29 patients of group L (120s) vs 27 others of group L (90s) and 22cases of group E with significant difference (p=0.02). Conclusion:We recommend waiting unless 90 or better 120 s following the loss of lid reflex before attempting iv placement in children receiving an sevoflurane inhalation.