Key result
3-aminobenzamide reduces BHP-induced pancreas and lung lesions in hamsters but not liver or gallbladder carcinogenesis.
Why the study?
The effects of 3-aminobenzamide on multiorgan carcinogenesis induced by N-nitrosobis(2-hydroxypropyl)amine in hamsters were investigated to understand organ-specific responses.
Does 3-aminobenzamide inhibit N-nitrosobis(2-hydroxypropyl)amine-induced multiorgan carcinogenesis in Syrian golden hamsters?
Does 3-aminobenzamide inhibit N-nitrosobis(2-hydroxypropyl)amine-induced multiorgan carcinogenesis in Syrian golden hamsters?
3-aminobenzamide inhibits BHP-induced carcinogenesis in the pancreas and lungs of hamsters, suggesting organ-specific effects of poly(ADP-ribose)polymerase inhibition.
The effects of an inhibitor of poly(ADP-ribose)polymerase, 3-aminobenzamide (ABA), on N-nitrosobis(2-hydroxypropyl)amine (BHP)-induced pancreas, liver, gallbladder and lung carcinogenesis in Syrian golden hamsters were investigated. Animals were given either BHP alone, by subcutaneous injection at a dose of 500 mg/kg body weight, or in combination with an intraperitoneal injection of ABA 30 min after the BHP at a dose of 300 or 600 mg/kg body weight once a week for 5 weeks, and then killed 35 weeks after the commencement of the experiment. ABA exerted inhibitory effects on pancreas and lung carcinogenesis induced by BHP, with mean numbers of lesions (including hyperplasias and carcinomas) being significantly decreased compared with the BHP-alone group values, while no significant effect was observed on liver or gallbladder carcinogenesis. These results suggest that the effects of ABA on carcinogenesis depend on the target organ as well as the chemical carcinogen examined.
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Tsujiuchi et al. (1991) studied BHP-induced multiorgan carcinogenesis. 3-aminobenzamide (ABA) vs. BHP alone was evaluated on Mean numbers of lesions (including hyperplasias and carcinomas) in pancreas, liver, gallbladder, and lung. 3-aminobenzamide significantly decreased the mean number of BHP-induced lesions in the pancreas and lung of Syrian golden hamsters compared to BHP alone, but had no significant effect on liver or gallbladder carcinogenesis.
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