Key result
Preconception severe mental disorders in primiparous women are not linked to adverse newborn outcomes.
Why the study?
One in four women of childbearing age have mental disorders and are prone to pregnancy complications and adverse offspring health outcomes, but the impact of preconception severe mental disorders on pregnancy outcomes in primiparous women was unclear.
Does preconception severe mental disorder affect pregnancy outcomes in primiparous women?
Cohort (n=6,189)
Does preconception severe mental disorder affect pregnancy outcomes in primiparous women?
Absolute Event Rate: 13% vs 11%
p-value: p=0.68
Despite severe preconception mental health disorders and lower socioeconomic status, pregnancy outcomes and newborn well-being in primiparous women were comparable to those without such disorders.
Background: One in four women of childbearing age has some degree of mental disorders and are, therefore, prone to both pregnancy complications and adverse health outcomes in their offspring. We aimed to evaluate the impact of preconception severe mental disorders on pregnancy outcomes in primiparous women. Methods: The study cohort was composed of 6,189 Finnish primiparous women without previously diagnosed diabetes, who delivered between 2009 and 2015, living in the city of Vantaa, Finland. Women were classified to have a preconception severe mental disorder if they had one or more outpatient visits to a psychiatrist or hospitalization with a psychiatric diagnosis 1 year before conception. Data on pregnancies, diagnoses, and pregnancy outcomes were obtained from national registers at an individual level. Results: < 0.001). Of all women, 3.4% had at least one psychiatric diagnosis. The most common psychiatric diagnoses were depression and anxiety disorders. The most common comorbidity was the combination of depression and anxiety disorders. There were no differences in the need for respiratory treatments, admissions to the neonatal intensive care unit, or antibiotic treatments between the offspring's groups. Conclusion: Although primiparous women had severe mental disorders, the well-being of newborns was good. The most common severe mental health disorders were depression and anxiety disorders, and psychiatric comorbidity was common. Women with severe mental disorders more often belonged to lower socioeconomic groups.
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Björkstedt et al. (2022) conducted a cohort in Pregnancy in primiparous women (n=6,189). Preconception severe mental disorders vs. No preconception psychiatric diagnosis was evaluated on Admission to neonatal intensive care unit (p=0.68). Preconception severe mental disorders in primiparous women were not associated with adverse newborn outcomes, including NICU admissions, respiratory treatments, or antibiotic treatments.
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