Key result
Low-dose unfractionated heparin linked to reduced postoperative hypercoagulability after abdominal aortic surgery.
Why the study?
The effect of low-dose heparin on postoperative hypercoagulability following abdominal aortic surgery was not well characterized.
Does low-dose unfractionated heparin reduce postoperative hypercoagulability in patients undergoing elective abdominal aortic surgery?
Observational (n=18)
Does low-dose unfractionated heparin reduce postoperative hypercoagulability in patients undergoing elective abdominal aortic surgery?
Low-dose unfractionated heparin effectively reduces postoperative hypercoagulability following elective abdominal aortic surgery, as demonstrated by thrombelastography.
Answers are grounded in this paper and cite their sources.
Low-dose heparin may not modify TEG hypercoagulability after aortic surgery; leaves open need for larger prospective validation.
The effect of low-dose heparin on postoperative hypercoagulability was assessed using thrombelastography (TEG) in eighteen patients undergoing elective abdominal aortic surgery. Patients received unfractionated heparin 5000IU bd SC commencing on the first postoperative day. Native whole blood TEG was performed preoperatively and on day two postoperatively. A heparinase-modified TEG was performed at the same time as the native whole blood TEG on day two. There were no significant changes in the postoperative native whole blood TEG variables (r, K, alpha, MA) relative to preoperative controls. In contrast, there were significant decreases in r and K, and increases in alpha in the heparinase-modified TEGs postoperatively (P < 0.01). There were significant differences between the postoperative native whole blood and heparinase-modified TEGs for all TEG variables (P < 0.01). The results indicate that low-dose heparin reduces postoperative hypercoagulability following abdominal aortic surgery as assessed by thrombelastography.
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Gibbs et al. (1998) conducted an observational in Elective abdominal aortic surgery (n=18). Low-dose unfractionated heparin vs. Preoperative baseline and heparinase-modified TEG was evaluated on Postoperative hypercoagulability assessed by thrombelastography (TEG) variables (r, K, alpha, MA) (p=<0.01). Low-dose unfractionated heparin reduced postoperative hypercoagulability following abdominal aortic surgery, with significant differences across all TEG variables (P<0.01).
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