Key result
Subcutaneous administration of 5,000 IU heparin twice daily resulted in no significant difference in blood coagulation and fibrinolysis parameters compared to control in prostatectomy patients.
Why the study?
Does low dose heparin alter blood coagulation parameters in patients undergoing transvesical prostatectomy?
RCT (n=21)
Double-blind
Does low dose heparin alter blood coagulation parameters in patients undergoing transvesical prostatectomy?
Low dose heparin prophylaxis does not significantly alter standard blood coagulation and fibrinolysis parameters in patients undergoing transvesical prostatectomy.
Answers are grounded in this paper and cite their sources.
Low-dose heparin can be used for prophylaxis in prostatectomy without affecting standard coagulation monitoring; confirms minimal systemic effects in this surgical setting.
Heparin was administered subcutaneously 5.000 IU twice daily using a double blind method to ten of twenty-one patients undergoing transvesical prostatectomy. Platelet count, APTT, throbin time, Reptilase time, Normotest, fibrinogen, Factor-VIII, ethanol gelation test, antithrombin III, fibrinolytic degradation products, alpha1-antitrypsin and alpha2-macroglobulin were studied pre- and postoperatively up to the 10th postoperative day. Statistical analysis of parameters of blood coagulation and fibrinolysis showed no significant difference between the two groups. The mechanism by which low dose heparin exerts its thromboprophylactic effect could not be elucidated from the study of the investigated parameters. The laboratory data gave no indication to a possible increased risk of postoperative hemorrhage.
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Hedlund et al. (1979) conducted an RCT in Transvesical prostatectomy (n=21). Heparin vs. Control was evaluated on Parameters of blood coagulation and fibrinolysis. Subcutaneous administration of 5,000 IU heparin twice daily resulted in no significant difference in blood coagulation and fibrinolysis parameters compared to control in prostatectomy patients.
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