Key result
Low molecular weight heparin resulted in a similar rate of postoperative deep vein thrombosis compared to unfractionated heparin (7.4% vs 7.9%) in patients undergoing abdominal surgery.
Why the study?
Does low molecular weight heparin prevent postoperative deep vein thrombosis in patients undergoing abdominal surgery compared to unfractionated heparin?
Population
653 patients undergoing abdominal surgery
Comparison
Low molecular weight heparin, 3,000 anti-Xa… vs Unfractionated heparin, 5,000 U subcutaneous…
Design
RCT, randomly allocated, double-blind
Follow-up
7 to 10 days
Authors
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LMWH offers convenient alternative to UFH for postoperative DVT prophylaxis; confirms comparable efficacy and safety in this RCT.
RCT (n=673)
Double-blind
randomly allocated
Yes
Does low molecular weight heparin prevent postoperative deep vein thrombosis in patients undergoing abdominal surgery compared to unfractionated heparin?
Absolute Event Rate: 7.4% vs 7.9%
Low molecular weight heparin once daily is as effective and safe as unfractionated heparin three times a day for preventing deep vein thrombosis after abdominal surgery.
Koppenhagen et al. (1992) conducted an RCT in postoperative deep vein thrombosis in abdominal surgery (n=673). Low molecular weight heparin vs. Unfractionated heparin (5,000 U subcutaneously three times a day) was evaluated on Postoperative deep vein thrombosis (DVT). Low molecular weight heparin resulted in a similar rate of postoperative deep vein thrombosis compared to unfractionated heparin (7.4% vs 7.9%) in patients undergoing abdominal surgery.
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