Why the study?
Does low-molecular-weight heparin reduce thromboembolic events and bleeding complications compared to unfractionated heparin in patients undergoing abdominal surgery?
Population
1351 patients scheduled to undergo abdominal surgery
Comparison
Low-molecular-weight heparin 1750 anti-Xa IU… vs Unfractionated heparin (UFH) 5000 IU twice a day
Design
RCT, randomized, double-blind
Authors
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LMWH preferred over UFH for VTE prophylaxis after abdominal surgery to reduce bleeding; reinforces its role as first-line agent in perioperative care.
Does low-molecular-weight heparin reduce thromboembolic events and bleeding complications compared to unfractionated heparin in patients undergoing abdominal surgery?
A low dose of LMWH (1750 anti-Xa IU daily) is as effective as UFH for postoperative VTE prophylaxis in abdominal surgery, with a significantly lower risk of bleeding.
Kakkar et al. (1997) studied this question.
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