April 22, 2009Haemostasis

Prospective Double-Blind Comparison between Fragmin and Conventional Low-Dose Heparin: Thromboprophylactic Effect and Bleeding Complications

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Why the study?

Does LMW heparin prevent deep vein thrombosis compared to conventional low-dose heparin in patients undergoing elective abdominal surgery?

Population

432 patients 40 years or older undergoing elective abdominal surgery (45% had malignant diseases)

Comparison

Low molecular weight heparin fragment vs Low-dose conventional heparin (5,000 IU/12 h)

Design

RCT, randomized, double-blind

Authors

DBDavid BergqvistVascular / Pulmonary Vascular UBU S BurmarkSwedish Orphan Biovitrum (Sweden)JFJan FrisellKarolinska University Hospital

Discussion

Member takes

Implication

LMW heparin increases bleeding without DVT benefit versus low-dose heparin; challenges its preference for prophylaxis in elective abdominal surgery.

Structured PICO

Does LMW heparin prevent deep vein thrombosis compared to conventional low-dose heparin in patients undergoing elective abdominal surgery?

Population

432 patients 40 years or older undergoing elective abdominal surgery (45% had malignant diseases)

Intervention

Low molecular weight (LMW) heparin fragment (5,000 antifactor Xa U/24 h)

Comparator

Low-dose conventional heparin (5,000 IU/12 h)

Outcome

Deep vein thrombosis (measured by 125I-fibrinogen)hard clinical

Single daily LMW heparin injection reduced DVT frequency to the same level as low-dose heparin twice daily, but caused significantly more bleeding complications at the studied dose.

Cite This Study

Bergqvist et al. (2009) studied this question.

synapsesocial.com/papers/6a7ac92fa861e9f59932bd4d https://doi.org/10.1159/000215351

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April 22, 2009Haemostasis

Prospective Double-Blind Comparison between Fragmin and Conventional Low-Dose Heparin: Thromboprophylactic Effect and Bleeding Complications

View Full Paper

Ask AI

Bookmark

Why the study?

Does LMW heparin prevent deep vein thrombosis compared to conventional low-dose heparin in patients undergoing elective abdominal surgery?

Population

432 patients 40 years or older undergoing elective abdominal surgery (45% had malignant diseases)

Comparison

Low molecular weight heparin fragment vs Low-dose conventional heparin (5,000 IU/12 h)

Design

RCT, randomized, double-blind

Authors

DBDavid BergqvistVascular / Pulmonary Vascular UBU S BurmarkSwedish Orphan Biovitrum (Sweden)JFJan FrisellKarolinska University Hospital

Discussion

Member takes

Implication

LMW heparin increases bleeding without DVT benefit versus low-dose heparin; challenges its preference for prophylaxis in elective abdominal surgery.

Structured PICO

Does LMW heparin prevent deep vein thrombosis compared to conventional low-dose heparin in patients undergoing elective abdominal surgery?

Population

432 patients 40 years or older undergoing elective abdominal surgery (45% had malignant diseases)

Intervention

Low molecular weight (LMW) heparin fragment (5,000 antifactor Xa U/24 h)

Comparator

Low-dose conventional heparin (5,000 IU/12 h)

Outcome

Deep vein thrombosis (measured by 125I-fibrinogen)hard clinical

Single daily LMW heparin injection reduced DVT frequency to the same level as low-dose heparin twice daily, but caused significantly more bleeding complications at the studied dose.

Cite This Study

Bergqvist et al. (2009) studied this question.

synapsesocial.com/papers/6a7ac92fa861e9f59932bd4d https://doi.org/10.1159/000215351

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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