Key result
Low molecular weight heparin resulted in 0% deep vein thrombosis compared to 2.2% with heparin calcium, and avoided severe hemorrhages that caused 5 control patients to suspend treatment.
Why the study?
Does low molecular weight heparin prevent post-surgical deep vein thrombosis and pulmonary embolism more safely than unfractionated heparin in patients undergoing abdominal surgery?
Population
90 patients undergoing abdominal surgery mainly for neoplasm, gallstones and gastric ulcers
Comparison
Low molecular weight heparin 7,500 AXaU… vs Heparin calcium 15,000 IU subcutaneously per day…
Design
Cohort, open
Follow-up
7 days
Authors
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May support LMWH preference for post-abdominal surgery DVT prophylaxis; leaves open confirmation in randomized trials.
Does low molecular weight heparin prevent post-surgical deep vein thrombosis and pulmonary embolism more safely than unfractionated heparin in patients undergoing abdominal surgery?
Absolute Event Rate: 0% vs 2.2%
Low molecular weight heparin is as effective as unfractionated heparin for preventing deep vein thrombosis after abdominal surgery, but demonstrates a superior safety profile with fewer severe bleeding events.
Garcea et al. (1992) studied Abdominal surgery (n=90). Low molecular weight heparin vs. Heparin calcium (15,000 IU subcutaneously per day) was evaluated on Deep vein thrombosis. Low molecular weight heparin resulted in 0% deep vein thrombosis compared to 2.2% with heparin calcium, and avoided severe hemorrhages that caused 5 control patients to suspend treatment.
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