What is the clinical evidence from this study?

Study design: Cohort. Population: Sarcoma of the lower extremity (n=14). Intervention: Vascular reconstruction. Primary outcome: Patency of the vascular reconstructions.

What does this research mean for the field?

Vascular reconstruction after limb-preserving resection for lower extremity sarcoma achieves high graft patency and maintains satisfactory limb function without local tumor recurrence. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate graft patency, limb salvage rates, functional outcomes, and long-term survival in patients undergoing vascular reconstruction during limb-preserving surgery for lower extremity sarcomas.

October 1, 1996Archives of Surgery

Vascular Reconstruction for Limb Salvage in Sarcoma of the Lower Extremity

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Key result

Vascular reconstruction after lower extremity sarcoma resection achieves ~93% graft patency with preserved limb function.

n=14

Why the study?

The patency and limb-salvage outcomes of vascular reconstruction in patients undergoing limb-preserving resection for lower extremity sarcomas were not well characterized.

Does vascular reconstruction provide acceptable patency and limb salvage in patients undergoing limb-preserving resection for lower extremity sarcoma?

Population

14 patients with sarcomas in the proximal lower extremity undergoing limb-preserving resection

Comparison

Vascular reconstruction with autologous venous grafts

Design

Retrospective cohort study at a tertiary referral center

Follow-up

Mean 55 months (range 15 to 132 months)

Authors

TKThomas KopernaLudwig-Maximilians-Universität München

Discussion

Member takes

Implication

Supports vascular reconstruction for limb salvage in extremity sarcoma; leaves open confirmation in larger prospective cohorts.

Key Points

To evaluate graft patency, limb salvage rates, functional outcomes, and long-term survival in patients undergoing vascular reconstruction during limb-preserving surgery for lower extremity sarcomas.
Retrospective cohort study analyzing 14 patients who underwent limb-preserving resection of proximal lower extremity sarcomas with 20 vascular reconstructions between 1984 and 1992 at a tertiary university hospital.
Assessed graft patency via color Doppler ultrasound, monitored limb function and quality of life clinically, and tracked local control and systemic recurrence over a follow-up of 15 to 132 months (mean 55 months).
Vascular grafts remained patent in 13 of 14 patients, with postoperative venous thrombosis occurring in 3 patients (successfully treated by thrombectomy in 2) and permanent occlusion in 1 patient.
Limb function was rated as excellent or good in 9 patients, fair in 3, and poor in 1, with no local tumor recurrences observed across the cohort.
Four patients died during follow-up due to systemic recurrence in the lung, while 2 additional patients developed pulmonary metastases but survived up to 132 months following surgical resection or chemotherapy.

Study Design

Type

Cohort (n=14)

Multicenter

Structured PICO

Does vascular reconstruction provide acceptable patency and limb salvage in patients undergoing limb-preserving resection for lower extremity sarcoma?

Population

14 patients with sarcomas of the proximal lower extremity who underwent limb-preserving resection and vascular reconstruction, followed for a mean of 55 months.

Exposure

Vascular reconstruction (20 reconstructions performed, primarily autologous venous grafts)

Outcome

Patency of vascular reconstructions (documented by Color Doppler scans)surrogate

Vascular reconstruction using autologous venous grafts is a viable and effective strategy for limb salvage in patients undergoing resection for lower extremity sarcomas, yielding high patency rates and satisfactory limb function.

Cite This Study

Thomas Koperna (1996) conducted a cohort in Sarcoma of the lower extremity (n=14). Vascular reconstruction was evaluated on Patency of the vascular reconstructions. Vascular reconstruction after limb-preserving resection for lower extremity sarcoma achieved graft patency in 92.9% of patients, maintaining satisfactory limb function with no local recurrences.

synapsesocial.com/papers/6aac87f3cf9c223f2df0fd2b https://doi.org/10.1001/archsurg.1996.01430220097023

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October 1, 1996Archives of Surgery

Vascular Reconstruction for Limb Salvage in Sarcoma of the Lower Extremity

View Full Paper

Ask AI

Bookmark

Key result

Vascular reconstruction after lower extremity sarcoma resection achieves ~93% graft patency with preserved limb function.

n=14

Why the study?

The patency and limb-salvage outcomes of vascular reconstruction in patients undergoing limb-preserving resection for lower extremity sarcomas were not well characterized.

Does vascular reconstruction provide acceptable patency and limb salvage in patients undergoing limb-preserving resection for lower extremity sarcoma?

Population

14 patients with sarcomas in the proximal lower extremity undergoing limb-preserving resection

Comparison

Vascular reconstruction with autologous venous grafts

Design

Retrospective cohort study at a tertiary referral center

Follow-up

Mean 55 months (range 15 to 132 months)

Authors

TKThomas KopernaLudwig-Maximilians-Universität München

Discussion

Member takes

Implication

Supports vascular reconstruction for limb salvage in extremity sarcoma; leaves open confirmation in larger prospective cohorts.

Key Points

To evaluate graft patency, limb salvage rates, functional outcomes, and long-term survival in patients undergoing vascular reconstruction during limb-preserving surgery for lower extremity sarcomas.
Retrospective cohort study analyzing 14 patients who underwent limb-preserving resection of proximal lower extremity sarcomas with 20 vascular reconstructions between 1984 and 1992 at a tertiary university hospital.
Assessed graft patency via color Doppler ultrasound, monitored limb function and quality of life clinically, and tracked local control and systemic recurrence over a follow-up of 15 to 132 months (mean 55 months).
Vascular grafts remained patent in 13 of 14 patients, with postoperative venous thrombosis occurring in 3 patients (successfully treated by thrombectomy in 2) and permanent occlusion in 1 patient.
Limb function was rated as excellent or good in 9 patients, fair in 3, and poor in 1, with no local tumor recurrences observed across the cohort.
Four patients died during follow-up due to systemic recurrence in the lung, while 2 additional patients developed pulmonary metastases but survived up to 132 months following surgical resection or chemotherapy.

Study Design

Type

Cohort (n=14)

Multicenter

Structured PICO

Does vascular reconstruction provide acceptable patency and limb salvage in patients undergoing limb-preserving resection for lower extremity sarcoma?

Population

14 patients with sarcomas of the proximal lower extremity who underwent limb-preserving resection and vascular reconstruction, followed for a mean of 55 months.

Exposure

Vascular reconstruction (20 reconstructions performed, primarily autologous venous grafts)

Outcome

Patency of vascular reconstructions (documented by Color Doppler scans)surrogate

Cite This Study

synapsesocial.com/papers/6aac87f3cf9c223f2df0fd2b https://doi.org/10.1001/archsurg.1996.01430220097023

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

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